The NYU-CUNY Prevention Research Center (PRC) is an innovative public-private partnership between a CEPH-accredited, minority-serving public school of public health (CUNY) and a leading academic medical school with expertise in population health and prevention research (New York University). Established in 2014, the NYU-CUNY PRC works to catalyze translation of evidence-based and innovative programs to increase access to care and disrupt the cycle of health disparities among hard-to-reach, socially disadvantaged populations.